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Proxyphylline

Catalog No. T5940 CAS 603-00-9

Synonyms: 7-(2-Hydroxypropyl)theophylline

Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.

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Proxyphylline, CAS 603-00-9

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.79%

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Description	Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.
In vitro	Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline[1]

Synonyms	7-(2-Hydroxypropyl)theophylline
Molecular Weight	238.24
Formula	C10H14N4O3
CAS No.	603-00-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 47 mg/mL (197.28 mM)

References and Literature

1. Kukovetz W R , G Pöch, Holzmann S . Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation[J]. Arzneimittel-Forschung, 1983, 33(10):1450-1454. 2. Takeda K , Katano Y , Nakagawa Y , et al. EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION[J]. The Japanese Journal of Pharmacology, 1977, 27(5):709-720. 3. Rasmussen F V , Waldorff S , Madsen L . Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline.[J]. Eur J Respir Dis, 1984, 65(1):20-27.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library GPCR Compound Library Anti-Parkinson's Disease Compound Library Neurotransmitter Receptor Compound Library Anti-Tumor Natural Product Library Metabolism Compound Library

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Keywords

Proxyphylline 603-00-9 GPCR/G Protein Metabolism Neuroscience Adenosine Receptor PDE Inhibitor P1 receptor inhibit 7-(2-Hydroxypropyl)theophylline inhibitor

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