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Progabide

Catalog No. T16581 CAS 62666-20-0

Synonyms: SL 76002, Halogabide, Gabren, Gabrene

Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.

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Progabide, CAS 62666-20-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 413.00
200 mg	In stock	$ 590.00
500 mg	In stock	$ 943.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.7%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Progabide (SL 76002) is an agonist of the gamma-aminobutyric acid receptor.

In vivo

Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].

Synonyms	SL 76002, Halogabide, Gabren, Gabrene
Molecular Weight	334.77
Formula	C17H16ClFN2O2
CAS No.	62666-20-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (672.1 mM), Sonication is recommended.

References and Literature

1. Manev H, et al. Progabide, a GABA mimetic drug, stimulates the secretion of plasma corticosterone in rats. Pharmacol Biochem Behav. 1987 Dec;28(4):443-6.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Antidepressant Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library ReFRAME Related Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Progabide 62666-20-0 Membrane transporter/Ion channel Neuroscience GABA Receptor SL 76002 SL-76002 Halogabide SL76002 Gabren Gabrene inhibitor inhibit

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