Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 77.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 339.00 | |
25 mg | In stock | $ 576.00 | |
50 mg | In stock | $ 825.00 | |
100 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 139.00 |
Description | PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm. |
Targets&IC50 | CK2:149 nM, p110α:173 nM, CK2α2:1.127 μM |
In vitro | PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[2].The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β[4] |
Synonyms | LY 294002, 4gamma-NH2 |
Molecular Weight | 322.36 |
Formula | C19H18N2O3 |
CAS No. | 942289-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.2 mg/mL (34.9 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PI-828 942289-87-4 Metabolism PI3K/Akt/mTOR signaling Stem Cells PI3K Casein Kinase LY 294002, 4gamma-NH2 PI 828 LY-294002, 4gamma-NH2 PI828 inhibitor inhibit