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Olinciguat

Catalog No. T16383 CAS 1628732-62-6

Synonyms: IW-1701

Olinciguat is an oral <a href="/target/Guanylate_cyclase" style="display: inline; color: #c13a36">Guanylate cyclase</a> (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.

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Olinciguat, CAS 1628732-62-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 264.00
5 mg	In stock	$ 540.00
10 mg	In stock	$ 819.00
25 mg	In stock	$ 1,474.00
50 mg	In stock	$ 2,067.00
100 mg	In stock	$ 2,980.00
200 mg	In stock	$ 4,470.00
1 mL * 10 mM (in DMSO)	In stock	$ 829.00

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Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Olinciguat is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.

Synonyms	IW-1701
Molecular Weight	509.39
Formula	C21H16F5N7O3
CAS No.	1628732-62-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (245.39 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Buys ES, et al. Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential. Nitric Oxide. 2018 Aug 1;78:72-80.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Clinical Compound Library Bioactive Compounds Library Max GPCR Compound Library NO PAINS Compound Library Orally Active Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Plecanatide Nelociguat Nitroprusside disodium dihydrate Methylene Blue LY83583 ODQ Runcaciguat Praliciguat

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Olinciguat 1628732-62-6 GPCR/G Protein Guanylate cyclase Inhibitor IW1701 IW 1701 Guanylate Cyclase inhibit IW-1701 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.