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Olinciguat

Name: Olinciguat
Brand: TargetMol
SKU: T16383
Price: 188 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16383Cas No. 1628732-62-6

Alias IW-1701

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.

Olinciguat

🥰Excellent

Purity: 99.71%

Catalog No. T16383Alias IW-1701Cas No. 1628732-62-6

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.

Pack Size	Price	Availability
1 mg	$188	In Stock
5 mg	$478	In Stock
10 mg	$689	In Stock
25 mg	$1,080	In Stock
50 mg	$1,480	In Stock
100 mg	$1,960	In Stock
1 mL x 10 mM (in DMSO)	$528	In Stock

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Batch Information

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Purity:99.71%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay.
Synonyms	IW-1701

Chemical Properties

Molecular Weight	509.39
Formula	C₂₁H₁₆F₅N₇O₃
Cas No.	1628732-62-6
Smiles	NC(=O)[C@](O)(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F
Relative Density.	1.62 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (245.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9631 mL	9.8157 mL	19.6313 mL	98.1566 mL
5 mM	0.3926 mL	1.9631 mL	3.9263 mL	19.6313 mL
10 mM	0.1963 mL	0.9816 mL	1.9631 mL	9.8157 mL
20 mM	0.0982 mL	0.4908 mL	0.9816 mL	4.9078 mL
50 mM	0.0393 mL	0.1963 mL	0.3926 mL	1.9631 mL
100 mM	0.0196 mL	0.0982 mL	0.1963 mL	0.9816 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc