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ORY1001

Catalog No. T6922   CAS 1431326-61-2
Synonyms: RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001

ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.

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ORY1001 Chemical Structure
ORY1001, CAS 1431326-61-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
2 mg In stock $ 76.00
5 mg In stock $ 136.00
10 mg In stock $ 246.00
25 mg In stock $ 475.00
50 mg In stock $ 695.00
100 mg In stock $ 988.00
500 mg In stock $ 1,980.00
1 mL * 10 mM (in DMSO) In stock $ 136.00
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Purity: 99.96%
Purity: 99.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ORY1001 (ORY 1001) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent aminoxidases with IC50 of <20 nM.
Targets&IC50 LSD1/KDM1A:20 nM
In vitro In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells. [1]
In vivo In rodent MV(4;11) xenografts, ORY-1001 (<0.020 mg/kg, p.o.) leads to significantly reduced tumor growth. [1]
Synonyms RG-6016, ORY-1001 (RG-6016) 2HCl, ORY-1001, ORY 1001
Molecular Weight 303.27
Formula C15H22N2·2HCl
CAS No. 1431326-61-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (16.48 mM)

Ethanol: 1 mg/mL(3.3 mM)

H2O: 56 mg/mL (184.7 mM)

TargetMolReferences and Literature

1. Maes T, et al. J Clin Oncol. 2013, 31, suppl; abstr. e13543. 2. Barbagallo C, Caltabiano R, Broggi G, et al. LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network[J]. Cancers. 2020, 12(12): 3867

TargetMolCitations

1. Barbagallo C, Caltabiano R, Broggi G, et al. LncRNA LINC00518 Acts as an Oncogene in Uveal Melanoma by Regulating an RNA-Based Network. Cancers. 2020, 12(12): 3867 2. Lv S, Zhao X, Zhang E, et al. Lysine demethylase KDM1A promotes cell growth via FKBP8-BCL2 axis in hepatocellular carcinoma. Journal of Biological Chemistry. 2022: 102374.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Highly Selective Inhibitor Library Anti-Cancer Drug Library Orally Active Compound Library Chromatin Modification Compound Library Histone Modification Compound Library Apoptosis Compound Library NO PAINS Compound Library Anti-Aging Compound Library

Related Products

Related compounds with same targets
LSD1-IN-6 KDM2B-IN-2 CP2 KF21213 Tranylcypromine (2-PCPA) hydrochloride ML324 SP2509 GSK467

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Keywords

ORY1001 1431326-61-2 Chromatin/Epigenetic Histone Demethylase RG-6016 RG 6016 ORY-1001 (RG-6016) 2HCl ORY-1001 (RG-6016) ORY-1001 RG6016 ORY 1001 inhibitor inhibit

 

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