Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
Description | Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . |
Targets&IC50 | NAMPT: |
In vitro | Nampt-IN-5 shows a good ADME data: mouse microsomal clearance, CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.Nampt-IN-5 has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1]. |
Molecular Weight | 427.5 |
Formula | C25H25N5O2 |
CAS No. | 2380013-17-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 48mg/ml(112.28mM, Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Nampt-IN-5 2380013-17-0 代谢 NAMPT P450 A2780 COR-L23 Nicotinamide phosphoribosyl transferase Inhibitor NamptIN5 Visfatin CYPs inhibit Pre-B cell colony enhancing factor PBEF Cytochrome P450 Nampt IN 5 inhibitor