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Nampt-IN-5

Catalog No. T12171 CAS 2380013-17-0

Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .

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Nampt-IN-5, CAS 2380013-17-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .
Targets&IC50	NAMPT:
In vitro	Nampt-IN-5 shows a good ADME data: mouse microsomal clearance, CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.Nampt-IN-5 has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays[1].

Molecular Weight	427.5
Formula	C25H25N5O2
CAS No.	2380013-17-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 48mg/ml(112.28mM, Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).ACS Med Chem Lett. 2019 Oct 10;10(11):1524-1529.

Related Products

Related compounds with same targets

Nampt activator-1 STF-118804 Nampt-IN-1 KPT9274 GNE-617 (E)-Daporinad CHS-828 GNE-618

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nampt-IN-5 2380013-17-0 代谢 NAMPT P450 A2780 COR-L23 Nicotinamide phosphoribosyl transferase Inhibitor NamptIN5 Visfatin CYPs inhibit Pre-B cell colony enhancing factor PBEF Cytochrome P450 Nampt IN 5 inhibitor

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