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N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide

Catalog No. T13215 CAS 339071-18-0

Synonyms: TS-011

N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide (TS-011) is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

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N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide Chemical Structure

N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide, CAS 339071-18-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
25 mg	In stock	$ 93.00
50 mg	In stock	$ 138.00

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Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide (TS-011) is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

In vivo

Administered at a dose of 0.3 mg/kg, TS-011 effectively inhibits the decrease in blood flow velocities observed at 1 and 7 hours post-reperfusion, as evidenced by significant statistical values (P<0.001), and prevents the acceleration of blood flow velocity at 24 hours after reperfusion (P<0.01). Additionally, this dosage of TS-011 substantially reduces the volume of infarcts by nearly 40% (P<0.05) and maintains microvascular perfusion areas, which are otherwise diminished in mice treated with a standard vehicle [1]. Furthermore, in a study involving 9 dogs experiencing delayed vasospasm, an acute intervention with TS-011 (1 mg/kg IV) markedly enlarged the basilar artery's diameter by 39%, illustrating a significant impact on vascular health [2].

Synonyms	TS-011
Molecular Weight	255.7
Formula	C11H14ClN3O2
CAS No.	339071-18-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 240 mg/mL (938.60 mM), Sonication is recommended.

References and Literature

1. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402. 2. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1350-4.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Human Metabolite Library ReFRAME Related Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide 339071-18-0 Others Inhibitor N (3 Chloro 4 morpholinophenyl) N' hydroxyformimidamide N(3Chloro4morpholinophenyl)N'hydroxyformimidamide TS 011 inhibit TS011 TS-011 inhibitor

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