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Milnacipran hydrochloride

Catalog No. T1189 CAS 101152-94-7

Synonyms: Dalcipran, 盐酸米那普仑, Milnacipran HCl, Savella

Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Levomilnacipran is an enantiomer of milnacipran, which is used to treat fibromyalgia. Levomilnacipran and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.

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Milnacipran hydrochloride, CAS 101152-94-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

norepinephrine transporter (NET):77 nM, norepinephrine transporter (SERT):420 nM

Synonyms	Dalcipran, 盐酸米那普仑, Milnacipran HCl, Savella
Molecular Weight	282.81
Formula	C15H23ClN2O
CAS No.	101152-94-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 28.3 mg/mL (100 mM)

DMSO: 28.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chen C, et al. Bioorg Med Chem Lett, 2008, 18(4), 1346-1349. 2. Ueta K, et al. Psychopharmacology (Berl), 2004, 175(2), 241-246. 3. Mochizuki D, et al. Psychopharmacology (Berl), 2002, 162(3), 323-332. 4. Moret C, et al. J Neurochem, 1997, 69(2), 815-822.

Related compound libraries

This product is contained In the following compound libraries：

Neurotransmitter Receptor Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Anti-Alzheimer's Disease Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

Related Products

Related compounds with same targets

Tampramine Reboxetine Nisoxetine hydrochloride (S)-Viloxazine Hydrochloride ARC 239 dihydrochloride Lofepramine DOV-216,303 Free Base Trimipramine maleate

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Milnacipran hydrochloride 101152-94-7 神经科学 Norepinephrine Serotonin Transporter 5-HTT inhibit Dalcipran SLC6A4 Milnacipran HCl Milnacipran Inhibitor Savella SERT inhibitor

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