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MS37452

Catalog No. T21767 CAS 423748-02-1

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).

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MS37452, CAS 423748-02-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 322.00
100 mg	In stock	$ 555.00
500 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
Targets&IC50	CBX7:43 µM (Ki)

Molecular Weight	398.45
Formula	C22H26N2O5
CAS No.	423748-02-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (150.58 mM)

References and Literature

1. Chunyan Ren, et al.Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.Chem Biol . 2015 Feb 19;22(2):161-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Epigenetics Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library NO PAINS Compound Library

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Related compounds with same targets

BAY-598 PFI-2 IHMT-EZH2-426 WDR5-0103 A-395 EZM 2302 MS049 PRMT5-IN-29

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MS37452 423748-02-1 Chromatin/Epigenetic Others Histone Methyltransferase transcription Inhibitor p16/CDKN2A anticancer H3K27me3 derepress CBX7 chromodomain MS 37452 MS-37452 inhibit INK4A/ARF inhibitor

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