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ML218

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Catalog No. T12076LCas No. 1346233-68-8

ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).

ML218
Other Forms of ML218:
ML218 hydrochlorideT120762319922-08-0
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ML218

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Purity: 99.45%
Catalog No. T12076LCas No. 1346233-68-8
ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$52-In Stock
5 mg$123In StockIn Stock
10 mg$197In StockIn Stock
25 mg$358-In Stock
50 mg$517-In Stock
1 mL x 10 mM (in DMSO)$162-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.45%
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Product Introduction

Bioactivity
Description
ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).
Targets&IC50
Cav3.3:270 nM, 270 nM:Ca2+ flux, Cav 3.2:310 nM
In vitro
In a voltage clamp experiment, bath application of 3 μM ML218 significantly reduced the T-type Ca2+ current by ∼45%[1].
In vivo
In Male Sprague-Dawley rats (275-299 g) induced by haloperidol,ML218 (0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg; Oral administration; once) treatment reversed cataleptic behavior in rats induced by a 0.75 mg/kg dose of haloperidol[1].
Chemical Properties
Molecular Weight369.33
FormulaC19H26Cl2N2O
Cas No.1346233-68-8
Smiles[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
Relative Density.1.184 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (270.76 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 5 mg/mL (13.54 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7076 mL13.5380 mL27.0761 mL135.3803 mL
5 mM0.5415 mL2.7076 mL5.4152 mL27.0761 mL
10 mM0.2708 mL1.3538 mL2.7076 mL13.5380 mL
20 mM0.1354 mL0.6769 mL1.3538 mL6.7690 mL
50 mM0.0542 mL0.2708 mL0.5415 mL2.7076 mL
100 mM0.0271 mL0.1354 mL0.2708 mL1.3538 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ML-218ML218ML 218Cav3.3Cav3.2CalciumChannelCalcium ChannelCa2+ flux
Related Tags: buy ML218 | purchase ML218 | ML218 cost | order ML218 | ML218 chemical structure | ML218 in vivo | ML218 in vitro | ML218 formula | ML218 molecular weight
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