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Laurocapram

Catalog No. T2A2509 CAS 59227-89-3

Synonyms: Tranzone, Azone, N-Lauryl caprolactam, N-0252, N-Dodecylcaprolactam

Laurocapram (N-Lauryl caprolactam) is a percutaneous enhancer. Upon application to the skin, laurocapram interacts with lipids in the stratum corneum and may enhance the ability of the skin to absorb a hydrophilic chemical.

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Laurocapram, CAS 59227-89-3

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Tranzone, Azone, N-Lauryl caprolactam, N-0252, N-Dodecylcaprolactam
Molecular Weight	281.48
Formula	C18H35NO
CAS No.	59227-89-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (177.63 mM)

References and Literature

1. Xue, X., Zhou, Y., Chen, Y., Meng, J., Jia, M., & Hou, Z. et al. (2011). Promoting effects of chemical permeation enhancers on insulin permeation across TR146 cell model of buccal epitheliumin vitro. Drug And Chemical Toxicology, 35(2), 199-207. doi: 10.3109/01480545.2011.589848 2. del Rio-Sancho, S., Serna-Jiménez, C., Calatayud-Pascual, M., Balaguer-Fernández, C., Femenía-Font, A., Merino, V., & López-Castellano, A. (2012). Transdermal absorption of memantine – Effect of chemical enhancers, iontophoresis, and role of enhancer lipophilicity. European Journal Of Pharmaceutics And Biopharmaceutics, 82(1), 164-170. doi: 10.12016/j.ejpb.2012.06.2005

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Laurocapram 59227-89-3 Others hydrophilic inhibit Inhibitor Absorption N0252 Tranzone N 0252 Azone N-Lauryl caprolactam N-0252 lipophilic enhancer N-Dodecylcaprolactam inhibitor

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