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Lappaol A

Catalog No. TN1072 CAS 62333-08-8

Lappaol A has Antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents.

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Lappaol A, CAS 62333-08-8

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Purity: 98%

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Description	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant anticancer agents.
In vitro	In this study, we isolated six lignans from A. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)Lappaol A, lappaol C, and lappaol F. The MDR reversal potential of the isolated lignans and the underlying mechanism of action were studied using two MDR cancer cell lines, CaCo2 and CEM/ADR 5000 which overexpress P-gp and other ABC transporters. In two-drug combinations of lignans with the cytotoxic doxorubicin, all lignans exhibited synergistic effects in CaCo2 cells and matairesinol, arctiin, lappaol C and lappaol F display synergistic activity in CEM/ADR 5000 cells. Additionally, in three-drug combinations of lignans with the saponin digitonin and doxorubicin MDR reversal activity was even stronger enhanced. The lignans can increase the retention of the P-gp substrate rhodamine 123 in CEM/ADR 5000 cells, indicating that lignans can inhibit the activity of P-gp.
Source	Natural Products > Orchidaceae > Gymnadenia

Molecular Weight	536.57
Formula	C30H32O9
CAS No.	62333-08-8

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store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.Phytomedicine. 2015 Feb 15;22(2):301-7.

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Keywords

Lappaol A 62333-08-8 MAPK Membrane transporter/Ion channel Neuroscience P-gp JNK inhibitor inhibit

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