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Microbiology/Virology Influenza Virus Laninamivir

Laninamivir

Catalog No. T15707   CAS 203120-17-6
Synonyms: R 125489

Laninamivir is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).

Laninamivir, CAS 203120-17-6
Pack Size Availability Price/USD Quantity
1 mg In stock 910.00
50 mg In stock 9403.00
100 mg In stock 14157.00
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Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Laninamivir is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).
Targets&IC50 N5 ,   p09N1 ,   p57N2
In vitro Laninamivir is effective against p57N2, p09N1, and N5 with a similar binding mode to Zanamivir. Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution [1].
Synonyms R 125489
Purity 100.00%
Molecular Weight 346.34
Formula C13H22N4O7
CAS No. 203120-17-6

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Water: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Clinical Compound Library Anti-virus Compound Library Drug Repurposing Library FDA Approved & Pharmacopeial Drug Library

Related Products

Related compounds with same targets
Laninamivir Baloxavir CBS1117 Dryocrassin ABBA S119-8 Tunicamycin Filixic acid ABA Diphyllin

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