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L-798106

Catalog No. T15689 CAS 244101-02-8

Synonyms: CM9, GW671021

L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, <5000 nM, and <5000 nM at EP4, EP1, and EP2, respectively).

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L-798106, CAS 244101-02-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
Targets&IC50	EP1/2 receptor:> 5000 nM(ki), EP3 receptor: 0.3 nM(ki), EP4 receptor:916 nM(ki)

Synonyms	CM9, GW671021
Molecular Weight	536.44
Formula	C27H22BrNO4S
CAS No.	244101-02-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Juteau H, et al. Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor. Bioorg Med Chem. 2001 Aug;9(8):1977-84.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-798106 244101-02-8 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor CM-9 CM9 L798106 GW 671021 CM 9 GW-671021 GW671021 L 798106 inhibitor inhibit

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