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L 756423

Catalog No. T24362 CAS 216863-66-0

Synonyms: L756423, MK-944a, MK944a, L-756,423, L-756423, MK 944a

L 756423 (L756423) is a novel potent and selective and competitive HIV protease inhibitor with a Ki value of 0.049 nM for HIV-1 PR.L 756423 blocks the spread of HIV(IIIb)-infected MT25 lymphocytes at 0.50-0.1 nM and can be used for the study of Acquired Immunodeficiency Syndrome (AIDS).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

L 756423, CAS 216863-66-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 390.00
5 mg	In stock	$ 928.00
10 mg	In stock	$ 1,260.00
25 mg	In stock	$ 1,880.00
50 mg	In stock	$ 2,530.00
100 mg	In stock	$ 3,420.00

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Purity: 100%

ee: 97.7%

Purity: 100%

ee: 98.76%

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Description	L 756423 (L756423) is a novel potent and selective and competitive HIV protease inhibitor with a Ki value of 0.049 nM for HIV-1 PR.L 756423 blocks the spread of HIV(IIIb)-infected MT25 lymphocytes at 0.50-0.1 nM and can be used for the study of Acquired Immunodeficiency Syndrome (AIDS).
In vitro	MK-944a (L-756,423) is selective and competitively inhibits HIV-1 PR with a K(i) value of 0.049 nM. It stops the spread of the HIV(IIIb)-infected MT4 lymphoid cells at 25.0-50.0 nM, even in the presence of alpha(1) acid glycoprotein, human serum albumin, normal human serum, or fetal bovine serum.[1]

Synonyms	L756423, MK-944a, MK944a, L-756,423, L-756423, MK 944a
Molecular Weight	652.82
Formula	C39H48N4O5
CAS No.	216863-66-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dorsey BD, et al. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem. 2000 Sep 7;43(18):3386-99. 2. Rose MJ, et al. Determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):425-35. 3. Rose MJ, et al. High-throughput simultaneous determination of the HIV protease inhibitors indinavir and L-756423 in human plasma using semi-automated 96-well solid phase extraction and LC-MS/MS. J Pharm Biomed Anal. 2000 Dec 15;24(2):291-305. 4. Rose MJ, et al. Determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):425-35.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 756423 216863-66-0 Microbiology/Virology Proteases/Proteasome HIV Protease L756423 MK-944a MK944a L-756,423 L-756423 MK 944a inhibitor inhibit

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