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Kansuinine A

Catalog No. TN4379 CAS 57701-86-7

Kansuinine A, a 95% ethanol extract from the roots of E. kansui, possesses an inhibitory effect on IL-6-induced STAT3 activation by activating ERK1/2.

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Kansuinine A, CAS 57701-86-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Kansuinine A, a 95% ethanol extract from the roots of E. kansui, possesses an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2.
In vitro	Kansuinine A markedly promoted SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL[3].

Molecular Weight	730.75
Formula	C37H46O15
CAS No.	57701-86-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: ≥ 100 mg/mL (136.85 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Stimulation of Nerve Growth Factor Production by Diterpenoids Isolated from Plants of Euphorbia Species. Bioscience, Biotechnology, and Biochemistry.1994 Aug 23:1749-1751. 2. Jong Sun Chang, et al. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010 Oct;76(14):1544-9. 3. Xiaoyun Shu, et al. Bioassay-guided separation of the proinflammatory constituents from the roots of Euphorbia kansui. J Nat Med. 2010 Jan;64(1):98-103.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Kansuinine A 57701-86-7 Immunology/Inflammation JAK/STAT signaling Stem Cells Interleukin IL Receptor STAT Interleukin Related inhibit Inhibitor inhibitor

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