Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrhythmic and cardioprotective properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 195.00 | |
5 mg | Inquiry | $ 437.00 | |
10 mg | Inquiry | $ 655.00 | |
25 mg | Inquiry | $ 1,178.00 | |
50 mg | Inquiry | $ 1,768.00 | |
100 mg | Inquiry | $ 2,652.00 | |
200 mg | Inquiry | $ 3,978.00 |
Description | JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrhythmic and cardioprotective properties. |
In vitro | JTV-519 Formate was able to suppress spontaneous Ca2+ release in FK506-treated HEK-293 cells co-expressing RyR2 and FKBP12.6. Furthermore, K201 suppressed spontaneous Ca2+ release in HEK-293 cells expressing RyR2 alone and in cells co-expressing RyR2 and FKBP12.6 with the same potency. [2] |
Synonyms | JTV-519 Formate (145903-06-6 Free base) |
Molecular Weight | 470.62 |
Formula | C26H34N2O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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JTV-519 Formate Membrane transporter/Ion channel Metabolism Others Calcium Channel JTV519 Formate JTV 519 Formate 145903-06-6 Free base JTV-519 Formate (145903-06-6 Free base) 145903-06-6 inhibitor inhibit