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JNJ-26990990

Catalog No. T27673 CAS 877316-38-6

JNJ-26990990 is a broad-spectrum anticonvulsant drug as a second-generation followup to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects associated with topiramate's carbonic anhydrase inhibition. It also has potential use in the treatment of inflammatory pain, neuropathic pain, and depression. JNJ-26990990 entered phase II clinical trials in October 2007.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JNJ-26990990, CAS 877316-38-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 302.00
10 mg	In stock	$ 447.00
25 mg	In stock	$ 738.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00
1 mL * 10 mM (in DMSO)	In stock	$ 275.00

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Purity: 95.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	242.32
Formula	C9H10N2O2S2
CAS No.	877316-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (268.24 mM)

References and Literature

1. Fiore A D , Simone G D , Alterio V , et al. The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies[J]. Organic & Biomolecular Chemistry, 2016, 14(21):4853-4858. 2. Lin R, Weaner LE, Hoerr DC, Salter R, Gong Y. Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites. J Labelled Comp Radiopharm. 2013 Jan;56(1):22-6. doi: 10.1002/jlcr.301Epub 2013 Jan 10. PubMed PMID: 24285137. 3. Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r. PubMed PMID: 19388676.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Bioactive Compounds Library Max ReFRAME Related Library Bioactive Compound Library Immunology/Inflammation Compound Library Antidepressant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JNJ-26990990 877316-38-6 Others JNJ 26990990 JNJ26990990 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.