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JND3229

Catalog No. T15615 CAS 2260886-64-2

JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JND3229, CAS 2260886-64-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 128.00
5 mg	In stock	$ 326.00
10 mg	In stock	$ 490.00
25 mg	In stock	$ 812.00
50 mg	In stock	$ 1,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 443.00

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Purity: 97.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma.
In vitro	JND3229 potently inhibits the proliferation of BaF3 cells (harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797Smutations), NCI-H1975 NSCLC cells (with EGFRT790M mutation) and A431 cancer cells (overexpressing EGFRWT) with IC50 values of 0.51, 0.32, 0.31 and 0.27 µM, respectively. JND3229 (0.1, 0.3, 1, 3, 10 µM; 2 h) potently inhibits the phosphorylation of EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S in engineering BaF3 cells[1].
In vivo	JND3229 (10 mg/kg; i.p.; twice daily for 10 days) exhibits an obvious suppression of tumor growth, and shows target inhibition in vivo[1].

Molecular Weight	617.18
Formula	C33H41ClN8O2
CAS No.	2260886-64-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.7 mg/mL (19 mM), Sonication is recommended.

References and Literature

1. Lu X, et al. Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018 Oct 8;9(11):1123-1127.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Inhibitor Library Membrane Protein-targeted Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Pancreatic Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JND3229 2260886-64-2 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR JND-3229 JND 3229 inhibitor inhibit

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