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JMJD7-IN-1

Catalog No. T9094 CAS 311316-96-8

Synonyms: Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester

JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.

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JMJD7-IN-1, CAS 311316-96-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 288.00
50 mg	In stock	$ 448.00
100 mg	In stock	$ 658.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
Targets&IC50	JMJD7:6.62 μM
In vitro	JMJD7-IN-1 efficiently binds to JMJD7, with an IC50 of 3.80 μM.?JMJD7-IN-1 (72 h) inhibits the growth of T-47d, SK-BR-3, Jurkat and Hela cells, with IC50s of 9.40 μM, 13.26 μM, 15.03 μM and 16.14 μM, respectively. JMJD7-IN-1 (0.1-1000 μM) dose-dependently inhibits the activity of JMJD7, with an IC50 of 6.62 μM.

Synonyms	Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester
Molecular Weight	363.15
Formula	C16H8Cl2N2O4
CAS No.	311316-96-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.64 mg/mL (10.01 mM)

References and Literature

1. Zhang W, et, al. Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation. Bioorg Med Chem Lett. 2021 May 25;45:128139.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Epigenetics Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Related compounds with same targets

GSK-LSD1 JQKD82 trihydrochloride YUKA1 KDM2B-IN-2 GSK2879552 GSK2879552 2HCl (1401966-69-5(free base)) Tranylcypromine (2-PCPA) hydrochloride KDM5A-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JMJD7-IN-1 311316-96-8 Chromatin/Epigenetic Others Histone Demethylase Inhibitor Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester cancer JMJD7 JMJD7 IN 1 inhibit JMJD7IN1 JMJD-7-IN-1 inhibitor

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