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JHU37160

Catalog No. T9018 CAS 2369979-68-8

Synonyms: JHU 37160

JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

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JHU37160, CAS 2369979-68-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 42.00
25 mg	In stock	$ 78.00
50 mg	In stock	$ 125.00
100 mg	In stock	$ 197.00
1 mL * 10 mM (in DMSO)	In stock	$ 32.00

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Purity: 99.25%

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Description	JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Targets&IC50	M3Dq DREADD (human):18.5 nM (EC50), M4Di DREADD (human):0.2 nM (EC50)
In vitro	JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells
In vivo	JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice

Synonyms	JHU 37160
Molecular Weight	358.84
Formula	C19H20ClFN4
CAS No.	2369979-68-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 72 mg/mL (200.65 mM)

DMSO: 72 mg/mL (200.65 mM)

References and Literature

1. Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Target-Focused Phenotypic Screening Library Neurotransmitter Receptor Compound Library Anti-Cardiovascular Disease Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Parkinson's Disease Compound Library

Related Products

Related compounds with same targets

Acetylcholine chloride Encenicline Atracurium besylate Olanzapine CHF5407 Metixene hydrochloride ZSET1446 Loganin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JHU37160 2369979-68-8 Neuroscience AChR JHU 37160 Inhibitor hM4Di Clozapine hM3Dq DREADD JHU-37160 inhibit Muscarinic acetylcholine receptor mAChR inhibitor

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