Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 278.00 | |
50 mg | In stock | $ 478.00 | |
100 mg | In stock | $ 689.00 |
Description | IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis. |
In vitro | IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[2]. Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[3]. |
Molecular Weight | 395.28 |
Formula | C17H22IN3 |
CAS No. | 193527-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.5 mg/mL (19.0 mM), when pH is adjusted to 3 with 1 M HCl. Sonication and heating to 60℃ are recommended.
Ethanol: 50 mMmg
You can also refer to dose conversion for different animals. More
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IPAG 193527-91-2 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibitor inhibit