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Hyperoside

Name: Hyperoside
Brand: TargetMol
SKU: T2844
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2844Cas No. 482-36-0

Alias Quercetin 3-galactoside, Hyperin

Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

Hyperoside

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Purity: 99.94%

Catalog No. T2844Alias Quercetin 3-galactoside, HyperinCas No. 482-36-0

Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$43	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$297	In Stock	In Stock
200 mg	$455	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Hyperoside AI Summary

Hyperoside exhibits multifaceted bioactivity, including antagonist activity at human mu, delta, and kappa opioid receptors, with selectivity for the mu receptor (Ke mu: 390 nM). It selectively inhibits the delta over the kappa receptor (Ki = 27.0 ratio). The compound also inhibits cow milk xanthine oxidase (43% at 50 µg/mL), and adenosine A1 receptors in rat brain membranes (86% at 100 µg/mL). It shows no significant activity against the 5HT1A receptor and inhibits HIV1 recombinant integrase (IC50: 64.6 µg/mL). Additionally, Hyperoside inhibits platelet aggregation induced by various stimuli and exhibits vasorelaxant properties in rat thoracic aorta contractions. It shows antiprotozoal activity against Giardia lamblia and Entamoeba histolytica (IC50: 85.1 and 108.9 µg/mL, respectively), as well as antioxidant activity (2.33 Trolox Units). The compound has antidepressant effects in rats, reducing immobility in forced swimming tests in a dose-dependent manner. In various assays, Hyperoside inhibits DNA polymerase Beta, Tau fibril formation, the ERK signaling pathway, glucosidases, aldolase, histone lysine methyltransferase, and others. It shows antibacterial activity against resistant strains (MIC > 128 µg/mL for some strains), and inhibits DNA gyrase and topoisomerases. The compound promotes glucose uptake in mouse C2C12 cells (EC50: 60,500 nM), exhibits hepatoprotective effects against CCL4-induced damage in mice, and shows antiamoebic activity (IC50: 143.61 µg/mL). Preliminary results also suggest inhibition of influenza neuraminidase and antiviral activity against Dengue virus (IC50: 1700 nM) and SARS-CoV-2. It exhibits sEH inhibition and anti-inflammatory properties, inhibits CDK5/p25, and demonstrates hepatoprotective as well as cytotoxic effects against certain cancer cell lines. Additionally, it shows antifungal activity against Candida species and Cryptococcus neoformans, and modulates various enzyme activities, including human OATP2B1 and FABP4. Hyperoside's diverse range of bioactivities, including potent antiplatelet, vasorelaxant, antimicrobial, antiviral, antioxidant, and enzyme inhibitory properties, highlights its potential for therapeutic applications across various conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.
Synonyms	Quercetin 3-galactoside, Hyperin

Chemical Properties

Molecular Weight	464.38
Formula	C₂₁H₂₀O₁₂
Cas No.	482-36-0
Smiles	OC[C@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.87 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 142 mg/mL (305.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1534 mL	10.7670 mL	21.5341 mL	107.6704 mL
5 mM	0.4307 mL	2.1534 mL	4.3068 mL	21.5341 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL	10.7670 mL
20 mM	0.1077 mL	0.5384 mL	1.0767 mL	5.3835 mL
50 mM	0.0431 mL	0.2153 mL	0.4307 mL	2.1534 mL
100 mM	0.0215 mL	0.1077 mL	0.2153 mL	1.0767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc