Shopping Cart

Your shopping cart is currently empty

Hemicholinium 3

Name: Hemicholinium 3
Brand: TargetMol
SKU: T2227
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T2227Cas No. 312-45-8

Alias Hemicholinium-3, Hemicholine

Hemicholinium 3 is a potent and selective choline uptake blocker.

Hemicholinium 3

Copy Product Info

🥰Excellent

Purity: 99.95%

Catalog No. T2227Alias Hemicholinium-3, HemicholineCas No. 312-45-8

Hemicholinium 3 is a potent and selective choline uptake blocker.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$66	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$217	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.95%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Hemicholinium 3 AI Summary

Hemicholinium 3 exhibits a diverse range of bioactivities. It is a potent inhibitor of the Acetylcholine transporter, with an IC50 value of 12.0 nM. Additionally, it inhibits the choline transporter in human PC-3 cells with an IC50 value of 36000.0 nM. Hemicholinium 3 also shows efficacy in inhibiting the proliferation of Plasmodium falciparum lines and various human enzymes such as JMJD2E, ALDH1A1, DNA Polymerase Beta, and Histone Lysine Methyltransferase G9a. It affects malarial parasite plastid, lipid storage, induces DNA re-replication in MCF 10a and SW480 cell lines, and has activity against DNA helicase RECQ1, polymerase iota, HCV, TDP-43, RAD52, and human APE1. Toxicity studies indicate that Hemicholinium 3 has an LD50 of 0.13 mg/kg and an LD95 of 0.2 mg/kg when administered intraperitoneally to CD-1 mice, with mortality rates influenced by co-administration of choline and neostigmine. Furthermore, the compound exhibits a low level of activity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hemicholinium 3 is a potent and selective choline uptake blocker.
Synonyms	Hemicholinium-3, Hemicholine

Chemical Properties

Molecular Weight	574.35
Formula	C₂₄H₃₄Br₂N₂O₄
Cas No.	312-45-8
Smiles	[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c1ccc(cc1)-c1ccc(cc1)C1(O)C[N+](C)(C)CCO1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (87.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7411 mL	8.7055 mL	17.4110 mL	87.0549 mL
5 mM	0.3482 mL	1.7411 mL	3.4822 mL	17.4110 mL
10 mM	0.1741 mL	0.8705 mL	1.7411 mL	8.7055 mL
20 mM	0.0871 mL	0.4353 mL	0.8705 mL	4.3527 mL
50 mM	0.0348 mL	0.1741 mL	0.3482 mL	1.7411 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc