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HBF-0259

Catalog No. T27527 CAS 957011-15-3

Synonyms: HBF 0259

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, <a href="/target/HBV" style="display: inline; color: #c13a36">HBV</a>-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.

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HBF-0259, CAS 957011-15-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 97.00
5 mg	In stock	$ 149.00
10 mg	In stock	$ 248.00
25 mg	In stock	$ 447.00
50 mg	In stock	$ 669.00
100 mg	In stock	$ 997.00
1 mL * 10 mM (in DMSO)	In stock	$ 223.00

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Purity: 99.88%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.

Synonyms	HBF 0259
Molecular Weight	364.21
Formula	C16H12Cl2FN5
CAS No.	957011-15-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 98 mg/mL (269.08 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70. doi: 10.1021/jm200696v. Epub 2011 Aug 2. PubMed PMID: 21786803; PubMed Central PMCID: PMC3158247. 2. Dougherty AM, Guo H, Westby G, Liu Y, Simsek E, Guo JT, Mehta A, Norton P, Gu B, Block T, Cuconati A. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37. Epub 2007 Sep 17. PubMed PMID: 17875990; PubMed Central PMCID: PMC2167973.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HBF-0259 957011-15-3 Immunology/Inflammation Antiviral HBsAg antigen HBV HBF 0259 virus hepatitis inhibit secretion HBF0259 Hepatitis B virus surface Inhibitor inhibitor

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