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Gramicidin
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Catalog No. T1130Cas No. 1405-97-6
Alias Gramicidinum, Gramicidine, Gramicidina
Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin dimers form ion channel-like pores in the cell membranes and organelles of bacterial and animal cells, allowing inorganic monovalent ions, such as potassium and sodium ions, to pass freely through the pores by diffusion, disrupting the important ionic gradient between membranes and thus killing the cells by various actions. Gramicidin is effective against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, but is not as effective against Gram-negative bacteria such as Escherichia coli.
Gramicidin
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Purity: 96.4%
Catalog No. T1130Alias Gramicidinum, Gramicidine, GramicidinaCas No. 1405-97-6
Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin dimers form ion channel-like pores in the cell membranes and organelles of bacterial and animal cells, allowing inorganic monovalent ions, such as potassium and sodium ions, to pass freely through the pores by diffusion, disrupting the important ionic gradient between membranes and thus killing the cells by various actions. Gramicidin is effective against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, but is not as effective against Gram-negative bacteria such as Escherichia coli.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $42 | - | In Stock | |
| 50 mg | $50 | - | In Stock | |
| 100 mg | $62 | - | In Stock | |
| 200 mg | $88 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $46 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:96.4%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin dimers form ion channel-like pores in the cell membranes and organelles of bacterial and animal cells, allowing inorganic monovalent ions, such as potassium and sodium ions, to pass freely through the pores by diffusion, disrupting the important ionic gradient between membranes and thus killing the cells by various actions. Gramicidin is effective against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, but is not as effective against Gram-negative bacteria such as Escherichia coli. |
| In vitro | METHODS: OC cells OVCAR8, A2780 and SKOV3 were treated with Gramicidin (0.33-3 µM) for 24-72 h. Cell viability was measured by WST-1 assay. RESULTS: Gramicidin inhibited the growth of OC cells in a dose- and time-dependent manner, with IC50 values of 0.0763, 0.1856 and 0.1148 µM for OVCAR8, SKOV3 and A2780 cells, respectively, at 72 h.[1] METHODS: Human gastric cancer cells SGC-7901 were treated with Gramicidin (0.3-3 µM) for 24-48 h. Apoptosis was detected by Flow cytometry. RESULTS: Gramicidin promoted apoptosis in SGC-7901 cells in a time- and dose-dependent manner. When cells were incubated with Gramicidin for 48 h, the percentage of viable cells decreased to 54.2% with 3 µM Gramicidin treatment compared to control. [2] |
| In vivo | METHODS: To study the effect on in vivo allograft survival, Gramicidin (2-4 mg/kg) was injected intraperitoneally into ectopic heart transplanted rats once daily for 6 days. RESULTS: Graft pulsation in the control group ceased at 5.4+/-0.4 days post-transplantation due to acute allograft rejection, whereas recipients in the group receiving intraperitoneal injections of Gramicidin (2-4 mg/kg) had a significant prolongation of graft pulsation to 15.4+/-4.3 or 18.4+/-3.9 days post-transplantation, respectively. [3] |
| Synonyms | Gramicidinum, Gramicidine, Gramicidina |
| Molecular Weight | 1882.33 |
| Formula | C99H140N20O17 |
| Cas No. | 1405-97-6 |
| Smiles | C[C@@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC7=CNC8=CC=CC=C87)C(=O)NCCO)NC(=O)CNC(=O)[C@H](C(C)C)NC=O |
| Relative Density. | no data available |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (26.56 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.06 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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