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Ginsenoside F4

Catalog No. TN1093   CAS 181225-33-2

Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its <a href="/pathway/Apoptosis" style="display: inline; color: #c13a36">Apoptosis</a>, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of <a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>-2 expression.

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Ginsenoside F4, CAS 181225-33-2
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression.
In vitro In this study, the inhibitory and apoptosis-inducing effect of Ginsenoside F4 (GF4) from steamed notoginseng was investigated by using human lymphocytoma Jurkat (JK) cell. Cell Counting Kit-8 method was then used to assess the anti-proliferative effect of GF4, and Western blotting was run to detect the expression level of two apoptosis-related proteins including Bax and the Bcl-2. The results suggested that GF4 can effectively inhibit the proliferation of the cells, and Bax expression increased gradually, but Bcl-2 expression reduced with the increase of GF4 concentration[1]
Molecular Weight 767.01
Formula C42H70O12
CAS No. 181225-33-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells.Nat Prod Res. 2013;27(24):2351-4.

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Keywords

Ginsenoside F4 181225-33-2 Apoptosis Immunology/Inflammation Proteases/Proteasome IL Receptor BCL MMP Ginsenoside F-4 Inhibitor inhibitor inhibit