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GNE-6776

Catalog No. T4634 CAS 2009273-71-4

Synonyms: GEN6776

GNE-6776 is a selective USP7 inhibitor.

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GNE-6776, CAS 2009273-71-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 79.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 310.00
25 mg	In stock	$ 630.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GNE-6776 is a selective USP7 inhibitor.
In vitro	GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases.
In vivo	Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay.

Synonyms	GEN6776
Molecular Weight	348.406
Formula	C20H20N4O2
CAS No.	2009273-71-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 310 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kategaya L, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 Oct 26;550(7677):534-538.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Orally Active Compound Library HIF-1 Signaling Pathway Compound Library Ubiquitination Compound Library DNA Damage & Repair Compound Library Anti-Cancer Compound Library Anti-Aging Compound Library Cell Cycle Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

Related Products

Related compounds with same targets

USP8-IN-2 USP8-IN-3 USP15-IN-1 IMP-1710 HBX 41108 LDN-91946 FT827 USP7-IN-6

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNE-6776 2009273-71-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB GNE6776 Deubiquitinase DUBs GEN6776 Inhibitor inhibit GNE 6776 inhibitor

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