Powder: -20°C for 3 years
In solvent: -80°C for 2 years
GNE-6776 is a selective USP7 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 310.00 | |
25 mg | In stock | $ 630.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 197.00 |
Description | GNE-6776 is a selective USP7 inhibitor. |
In vitro | GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases. |
In vivo | Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay. |
Synonyms | GEN6776 |
Molecular Weight | 348.406 |
Formula | C20H20N4O2 |
CAS No. | 2009273-71-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 310 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GNE-6776 2009273-71-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB GNE6776 Deubiquitinase DUBs GEN6776 Inhibitor inhibit GNE 6776 inhibitor