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GNE-6776

GNE-6776
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GNE-6776

Catalog No. T4634Cas No. 2009273-71-4
GNE-6776 is a selective USP7 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$74In Stock
5 mg$178In Stock
10 mg$287In Stock
25 mg$552In Stock
50 mg$793In Stock
100 mg$1,080In Stock
1 mL x 10 mM (in DMSO)$197In Stock
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Product Introduction

Bioactivity
Description
GNE-6776 is a selective USP7 inhibitor.
In vitro
GNE-6776 non-covalently targets USP7 12?? distant from the catalytic cysteine. GNE-6776 attenuates ubiquitin binding and thus inhibits USP7 deubiquitinase activity. GNE-6776 interacts with acidic residues that mediate hydrogen-bond interactions with the ubiquitin Lys48 side chain. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways.GNE-6776 selectively inhibits recombinant USP7 relative to 36 other deubiquitinases. GNE-6776 remains selective even at 100?μM, a more than sixfold higher concentration than used in cellular assays. GNE-6776 significantly inhibits USP7 while remaining selective against 44-47 other detected deubiquitinases.
In vivo
Although efficacious exposure is only transiently achieved, GNE-6776 causes modest, although significant, EOL-1 xenograft growth delay.
AliasGEN6776
Chemical Properties
Molecular Weight348.4
FormulaC20H20N4O2
Cas No.2009273-71-4
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 310 mg/mL

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