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Azvudine

Catalog No. T14489 CAS 1011529-10-4

Synonyms: RO-0622, FNC

Azvudine is a potent nucleoside Reverse Transcriptase inhibitor (NRTI), with Antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

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Azvudine, CAS 1011529-10-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Azvudine is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
Targets&IC50	HIV-2:0.025 nM(EC50), HIV-1:0.03 to 6.92 Nm(EC50)
In vitro	Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively.

Synonyms	RO-0622, FNC
Molecular Weight	286.22
Formula	C9H11FN6O4
CAS No.	1011529-10-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5.2 mg/ml (18.17 mM)

H2O: 50 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azvudine 1011529-10-4 Microbiology/Virology Proteases/Proteasome HBV HIV Protease Reverse Transcriptase HCV Protease resistant Human immunodeficiency virus NRTI RO 0622 inhibit mutation Inhibitor RO-0622 HCV Hepatitis C virus Hepatitis B virus HIV FNC analogue RO0622 inhibitor

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