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Azvudine

Catalog No. T14489 CAS 1011529-10-4

Synonyms: FNC, RO-0622

Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

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Azvudine, CAS 1011529-10-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
5 mg	In stock	$ 139.00
10 mg	In stock	$ 230.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 1,040.00
1 mL * 10 mM (in DMSO)	In stock	$ 131.00

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Purity: 100%

Purity: 99.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
Targets&IC50	HIV-2:0.025 nM(EC50), HIV-1:0.03 to 6.92 Nm(EC50)
In vitro	Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively.

Synonyms	FNC, RO-0622
Molecular Weight	286.22
Formula	C9H11FN6O4
CAS No.	1011529-10-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.2 mg/ml (18.17 mM)

H2O: 50 mg/mL

References and Literature

1. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Human Metabolite Library Anti-Infection Compound Library Clinical Compound Library Anti-Viral Compound Library ReFRAME Related Library Bioactive Compound Library

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Keywords

Azvudine 1011529-10-4 Microbiology/Virology Proteases/Proteasome HBV HIV Protease Reverse Transcriptase HCV Protease resistant Human immunodeficiency virus NRTI inhibit mutation RO 0622 Inhibitor HCV Hepatitis C virus Hepatitis B virus HIV analogue FNC RO-0622 RO0622 inhibitor

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