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Azvudine

Azvudine
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Purity:100%
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Azvudine

Catalog No. T14489Cas No. 1011529-10-4
Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
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Pack SizePriceAvailabilityQuantity
1 mg$57In Stock
5 mg$139In Stock
10 mg$230In Stock
25 mg$455In Stock
50 mg$686In Stock
100 mg$1,040In Stock
1 mL x 10 mM (in DMSO)$131In Stock
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Product Introduction

Bioactivity
Description
Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
In vitro
Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively.
AliasFNC, RO-0622
Chemical Properties
Molecular Weight286.22
FormulaC9H11FN6O4
Cas No.1011529-10-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 50 mg/mL
DMSO: 5.2 mg/ml (18.17 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
20 mM0.1747 mL0.8735 mL1.7469 mL8.7345 mL
50 mM0.0699 mL0.3494 mL0.6988 mL3.4938 mL
100 mM0.0349 mL0.1747 mL0.3494 mL1.7469 mL

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