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Efaproxiral Sodium

Catalog No. T6482 CAS 170787-99-2

Synonyms: RSR13 sodium

Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

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Efaproxiral Sodium, CAS 170787-99-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 46.00
50 mg	In stock	$ 67.00
100 mg	In stock	$ 98.00
200 mg	In stock	$ 143.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 99.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.
In vitro	Efaproxiral, a synthetic allosteric modifier of hemoglobinoxygen binding affinity, has been shown to bind reversibly to hemoglobin, stabilizing the deoxyhemoglobin tetramer conformation to reduce its affinity for oxygen. [1]
In vivo	Efaproxiral plus oxygen breathing reduces the radiobiological hypoxic fraction of EMT6 tumors from the value of 24% found in both air-breathing and oxygen-breathing mice to 9% and improves the response of the tumors to radiation. Carboplatin (100 mg/kg) slowes tumor growth in air-breathing mice, producing a growth delay of 3.3 days. Efaproxiral plus oxygen increases the growth delay to 5.7 days; this is 2.4 days (71%) greater than that for carboplatin alone and 2.1 days (57%) greater than that for carboplatin plus oxygen breathing. Efaproxiral plus oxygen breathing, therefore, improves the tumor growth delay obtained with 100 mg/kg carboplatin to or beyond that obtained with the highly toxic dose of 150 mg/kg carboplatin, but does so without increasing the toxicity beyond that seen with 100 mg/kg carboplatin in air-breathing mice.[1] Efaproxiral significantly increases tumor oxygenation by 8.4 to 43.4 mmHg within 5 days in C3H mice with RIF-1 tumors, with maximum increases at 22-31 min after treatment. Efaproxiral plus oxygen plus Radiation produces tumor growth inhibition throughout the treatment duration in C3H mice with RIF-1 tumors, and inhibition is significantly different from radiation plus oxygen from day 3 to day 5. [2]

Synonyms	RSR13 sodium
Molecular Weight	363.38
Formula	C20H23NO4·Na
CAS No.	170787-99-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 68 mg/mL (187.1 mM)

H2O: 67 mg/mL (184.4 mM)

Ethanol: 68 mg/mL (187.1 mM)

References and Literature

1. Donnelly ET, et al. Exp Biol Med (Maywood), 2006, 231(3), 317-321. 2. Hou H, et al. Radiat Res, 2007, 168(2), 218-225.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Ferroptosis Compound Library Bioactive Compounds Library Max Pyroptosis Compound Library Anti-Ovarian Cancer Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Efaproxiral Sodium 170787-99-2 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species RSR-13 RSR13 RSR 13 RSR13 sodium Inhibitor inhibit Efaproxiral inhibitor

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