Shopping Cart

Your shopping cart is currently empty

Ecopipam

Name: Ecopipam
Brand: TargetMol
SKU: T31602
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T31602Cas No. 112108-01-7

Alias UNII-0X748O646K, Sch-39166, Sch 39166

Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1/D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.

Ecopipam

🥰Excellent

Purity: 99.68%

Catalog No. T31602Alias UNII-0X748O646K, Sch-39166, Sch 39166Cas No. 112108-01-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$185	In Stock	In Stock
25 mg	$372	In Stock	In Stock
50 mg	$596	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.68%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1/D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.
Targets&IC50	α2A-adrenoceptor:731 nM (Ki), D4 Receptor:5520 nM (Ki), D2 Receptor:980 nM (Ki), D5 receptor:2.0 nM (Ki), 5-HT receptor:80 nM (Ki), D1 receptor:1.2 nM (Ki)
In vitro	Ecopipam (2 μM) completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].
In vivo	Ecopipam (0.003-0.3 mg/kg; a single s.c.) abolishes nicotine-induced enhancement of a sensory reinforcer in adult rats[3]. Ecopipam (10 mg/kg, oral administration) antagonizes apomorphine-induced stereotypy in rats[4]. Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].
Synonyms	UNII-0X748O646K, Sch-39166, Sch 39166

Chemical Properties

Molecular Weight	313.82
Formula	C₁₉H₂₀ClNO
Cas No.	112108-01-7
Smiles	CN1[C@@]2([C@@](C=3C(=CC(Cl)=C(O)C3)CC1)(C=4C(CC2)=CC=CC4)[H])[H]
Relative Density.	1.220 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (191.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.97 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1865 mL	15.9327 mL	31.8654 mL	159.3270 mL
5 mM	0.6373 mL	3.1865 mL	6.3731 mL	31.8654 mL
10 mM	0.3187 mL	1.5933 mL	3.1865 mL	15.9327 mL
20 mM	0.1593 mL	0.7966 mL	1.5933 mL	7.9664 mL
50 mM	0.0637 mL	0.3187 mL	0.6373 mL	3.1865 mL
100 mM	0.0319 mL	0.1593 mL	0.3187 mL	1.5933 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc