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TargetMol | Compound Library

MAPK Inhibitor Library

Catalog No. L1400

Mitogen-activated protein kinases (MAPKs) are a highly conserved family of serine/threonine protein kinases involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival. A broad range of extracellular stimuli including mitogens, cytokines, growth factors, and environmental stressors stimulate the activation of one or more MAPKK kinases (MAPKKKs) via receptor-dependent and -independent mechanisms. MAPKKKs then phosphorylate and activate a downstream MAPK kinase (MAPKK), which in turn phosphorylates and activates MAPKs.

The MAPK Inhibitor Library by TargetMol, containing 500 compounds targeting MAPK signaling, can be used for research in MAPK signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1400

MAPK Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 500 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Library Customization | TargetMol Library Customization

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Library Customization | TargetMol Library Composition

Ras
p38 MAPK
ERK
Apoptosis
Autophagy
Raf
MAPK
JNK
MEK
NF-κB
Kras
S6 Kinase
Akt
CDK
Src
TNF
VEGFR
Endogenous Metabolite
Caspase
Bcl-2 Family
Rho
PI3K
ROS
MNK
STAT
Antibacterial
PDGFR
NO Synthase
COX
FLT
c-Kit
mTOR
Casein Kinase
MLK
Parasite
DNA/RNA Synthesis
Aurora Kinase
GSK-3
PKA
TGF-beta/Smad
Ferroptosis
FGFR
Antifungal
PKC
Interleukin
IGF-1R
PARP
IL Receptor
MMP
ROCK
Cytochromes P450
Bcr-Abl
FAK
c-RET
PERK
ASK
Influenza Virus
JAK
AMPK
Reactive Oxygen Species
Dehydrogenase
Antiviral
SGK
Tie-2
TOPK
HSP
EGFR
Nrf2
PPAR
Serine Protease
c-Fms
KLF
Syk
Transferase
Anti-infection
Histone Methyltransferase
PYK2
Drug Metabolite
Mitophagy
Calcium Channel
Virus Protease
Tyrosine Kinases
Wnt/beta-catenin
Cholinesterase (ChE)
ALK
IRAK
Antibiotic
TLR
Gamma-secretase
Mitochondrial Metabolism
Chk
Trk receptor
Potassium Channel
HIF/HIF Prolyl-Hydroxylase
Necroptosis
Pim
PDK
RIP kinase
Antifection
Epigenetic Reader Domain
AChR
PROTACs
Antioxidant
HSV
GPCR
DYRK
GTPase
c-Myc
PAK
PD-1/PD-L1
HCV Protease
Aryl Hydrocarbon Receptor
PTEN
P-gp
Tyrosinase
Apelin receptor
LIM Kinase
Immunology/Inflammation related
NMDAR
PI4K
IFNAR
BACE
TRP/TRPV Channel
Adrenergic Receptor
ACK1
CaMK
Lipid
transporter
Beta Amyloid
5-HT Receptor
BMI-1
NOD-like Receptor (NLR)
AhR
Estrogen/progestogen Receptor
UGT
PGE Synthase
Survivin
DAPK
Protease-activated Receptor
Kinesin
Histamine Receptor
AAK1
CSF-1R
Glucosidase
DNA Alkylation
Beta-Secretase
IκB/IKK
ATPase
HBV
iGluR
IAP
GluR
Hippo pathway
Hydroxylase
HER
Y Box Binding Protein 1
c-Met/HGFR
Adenosine Receptor
BTK
cAMP
Ephrin Receptor
PAI-1
MELK
Aromatase
MDM-2/p53
Sodium Channel
MyD88
Glutathione Peroxidase
Phosphatase
Serine/threonin kinase
Topoisomerase
PDE
LDL
Cadherin
Prostaglandin Receptor
LRRK2
Pyroptosis
GPX
RXFP receptor
Cannabinoid Receptor
NADPH-oxidase
p53

Keywords