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Diazinon

Name: Diazinon
Brand: TargetMol
SKU: T0998
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0998Cas No. 333-41-5

Alias Dimpylate

Diazinon (Dimpylate) is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of pests including cockroaches, silverfish, ants, and fleas.

Diazinon

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Purity: 98%

Catalog No. T0998Alias DimpylateCas No. 333-41-5

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$37	In Stock	In Stock
500 mg	$66	-	In Stock
1 g	$94	-	In Stock
2 g	$136	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:Transparent to Yellow

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Product Introduction

Diazinon AI Summary

Diazinon demonstrates a multifaceted profile with various bioactivities and physico-chemical properties. It exhibits a range of permeability coefficients and partition coefficients, with apparent permeability values (Papp) through artificial membranes spanning from 5.21 to 31.14 × 10^-6 cm/s. Its LogP values fluctuate between -4.51 and 5.28 across different assays, and its log P is consistently measured at 3.3 in octanol-water. Biologically, Diazinon functions as an agonist of the Thyroid Stimulating Hormone Receptor, with a potency of 10.0 nM in HEK 293 cells. It shows cytotoxicity against p53-mutant cancer cells at 5.0 nM and inhibits various enzymes including ALDH1A1 (35481.3 nM), HADH2 (3162.3 nM), and HDAC6 (-5.84% to -9.02%). The compound activates multiple signaling pathways such as Cytochrome P450 3A4 (5011.9 nM) and the glucocorticoid receptor (10000.0 nM), while also acting on the human pregnane X receptor (2818.4 nM). In terms of antiviral activity, it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells, with inhibition percentages varying from 0.25% to 1.13% at 10 µM. The compound also interferes with SARS-CoV-2 3CL-Pro protease at 20 µM, showing inhibition rates of 8.471% to 10.6%. Diazinon demonstrates significant insecticidal activity against several pests, including Cheumatopsyche brevilineata, Daphnia magna, and small brown planthoppers, with varying EC50 and LD50 values. Additionally, it enhances grain yield in Lepidoptera-infected rice plants when applied at specific rates. Overall, Diazinon is a versatile compound with potential applications in pharmacology, agriculture, and antiviral research due to its diverse bioactivity spectrum and robust physicochemical properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diazinon (Dimpylate) is a thiophosphoric acid ester, functioning as a nonsystemic organophosphate insecticide that effectively targets and controls a variety of pests including cockroaches, silverfish, ants, and fleas.
Synonyms	Dimpylate

Chemical Properties

Molecular Weight	304.35
Formula	C₁₂H₂₁N₂O₃PS
Cas No.	333-41-5
Smiles	O(P(OCC)(OCC)=S)C1=NC(C(C)C)=NC(C)=C1
Relative Density.	1.117

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (147.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2857 mL	16.4285 mL	32.8569 mL	164.2845 mL
5 mM	0.6571 mL	3.2857 mL	6.5714 mL	32.8569 mL
10 mM	0.3286 mL	1.6428 mL	3.2857 mL	16.4285 mL
20 mM	0.1643 mL	0.8214 mL	1.6428 mL	8.2142 mL
50 mM	0.0657 mL	0.3286 mL	0.6571 mL	3.2857 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc