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Dalzanemdor

Catalog No. T62839 CAS 1629853-48-0

Synonyms: SAGE-718

Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.

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Dalzanemdor, CAS 1629853-48-0

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5 mg	In stock	$ 1,470.00
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50 mg	8-10 weeks	Inquiry

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Purity: 98.20%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
In vivo	SAGE-718 (Dalzanemdor) (5), a potent and high intrinsic activity NMDAR PAM with an optimized pharmacokinetic profile for oral dosing. Compound 5 has completed phase 1 single ascending dose and multiple ascending dose clinical trials and is currently undergoing phase 2 clinical trials for the treatment of cognitive impairment in Huntington's disease.[2]

Synonyms	SAGE-718
Molecular Weight	456.62
Formula	C27H43F3O2
CAS No.	1629853-48-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

chloroform: 5.68mg/mL (12.44mM), Sonication is recommended.

References and Literature

1. Beckley JT, et al. Pharmacological characterization of SAGE-718, a novel NMDA receptor positive allosteric modulator. Br J Pharmacol. 2023 Sep 12. 2. Hill MD, et al. SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the P doi: 10.1021/acs.jmedchem.2c00313. Epub 2022 Jul PMID: 35785990.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

Dalzanemdor 1629853-48-0 Membrane transporter/Ion channel Neuroscience NMDAR iGluR SAGE-718 SAGE718 SAGE 718 inhibitor inhibit

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