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Angiogenesis EGFR Dacomitinib hydrate

Dacomitinib hydrate

Catalog No. T19965   CAS 1042385-75-0
Synonyms: PF 299804, PF-299804, PF-299804, PF299804, PF 00299804, PF00299804, PF-00299804,

Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

Dacomitinib hydrate, CAS 1042385-75-0
Pack Size Availability Price/USD Quantity
2 mg In stock 97.00
5 mg In stock 147.00
10 mg In stock 216.00
25 mg In stock 373.00
50 mg In stock 559.00
100 mg In stock 839.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Dacomitinib hydrate is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
Targets&IC50
Synonyms PF 299804 , PF-299804 , PF-299804 , PF299804 , PF 00299804 , PF00299804 , PF-00299804 ,
Purity 98.00%
Molecular Weight 487.96
Formula C24H27ClFN5O3
CAS No. 1042385-75-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Ou SH, Soo RA. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era? Drug Des Devel Ther. 2015 Oct 15;9:5641-53. doi: 10.2147/DDDT.S52787. eCollection 2015. Review. PubMed PMID: 26508839. 2. Ramalingam SS, Jänne PA, Mok T, O'Byrne K, Boyer MJ, Von Pawel J, Pluzanski A, Shtivelband M, Docampo LI, Bennouna J, Zhang H, Liang JQ, Doherty JP, Taylor I, Mather CB, Goldberg Z, O'Connell J, Paz-Ares L. Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2014 Nov;15(12):1369-78. doi: 10.1016/S1470-2045(14)70452-8. Epub 2014 Oct 15. PubMed PMID: 25439691. 3. Giri N, Masters JC, Plotka A, Liang Y, Boutros T, Pardo P, O'Connell J, Bello C. Investigation of the impact of hepatic impairment on the pharmacokinetics of dacomitinib. Invest New Drugs. 2015 Aug;33(4):931-41. doi: 10.1007/s10637-015-0256-0. Epub 2015 Jun 6. PubMed PMID: 26048096. 4. Ellis PM, Shepherd FA, Millward M, et al. Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial. Lancet Oncol. 2014 Nov;15(12):1379-88. doi: 10.1016/S1470-2045(14)70472-3. Epub 2014 Oct 15. PubMed PMID: 25439692.

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EGFR-IN-7 Cetuximab (anti-EGFR) Panitumumab CP724714 O-Desmethyl gefitinib Dacomitinib hydrate CP-380736 Nimotuzumab

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