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Dacomitinib hydrate

Catalog No. T19965   CAS 1042385-75-0
Synonyms: PF 299804, PF00299804, PF 00299804, PF-00299804, PF299804, PF-299804

Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

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Dacomitinib hydrate Chemical Structure
Dacomitinib hydrate, CAS 1042385-75-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 122.00
25 mg In stock $ 179.00
50 mg In stock $ 239.00
100 mg In stock $ 372.00
500 mg In stock $ 869.00
1 mL * 10 mM (in DMSO) In stock $ 91.00
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Purity: 98.05%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
Synonyms PF 299804, PF00299804, PF 00299804, PF-00299804, PF299804, PF-299804
Molecular Weight 487.96
Formula C24H27ClFN5O3
CAS No. 1042385-75-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (112.71 mM)

TargetMolReferences and Literature

1. Ou SH, Soo RA. Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era? Drug Des Devel Ther. 2015 Oct 15;9:5641-53. doi: 10.2147/DDDT.S52787. eCollection 2015. Review. PubMed PMID: 26508839. 2. Ramalingam SS, Jänne PA, Mok T, O'Byrne K, Boyer MJ, Von Pawel J, Pluzanski A, Shtivelband M, Docampo LI, Bennouna J, Zhang H, Liang JQ, Doherty JP, Taylor I, Mather CB, Goldberg Z, O'Connell J, Paz-Ares L. Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2014 Nov;15(12):1369-78. doi: 10.1016/S1470-2045(14)70452-8. Epub 2014 Oct 15. PubMed PMID: 25439691. 3. Giri N, Masters JC, Plotka A, Liang Y, Boutros T, Pardo P, O'Connell J, Bello C. Investigation of the impact of hepatic impairment on the pharmacokinetics of dacomitinib. Invest New Drugs. 2015 Aug;33(4):931-41. doi: 10.1007/s10637-015-0256-0. Epub 2015 Jun 6. PubMed PMID: 26048096. 4. Ellis PM, Shepherd FA, Millward M, et al. Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial. Lancet Oncol. 2014 Nov;15(12):1379-88. doi: 10.1016/S1470-2045(14)70472-3. Epub 2014 Oct 15. PubMed PMID: 25439692.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Tyrosine Kinase Inhibitor Library Highly Selective Inhibitor Library Drug Repurposing Compound Library Kinase Inhibitor Library NO PAINS Compound Library JAK-STAT Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Dacomitinib hydrate 1042385-75-0 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR PF 299804 PF00299804 PF 00299804 PF-00299804 Dacomitinib Hydrate PF299804 PF-299804 inhibitor inhibit

 

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