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DL-Menthol
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Catalog No. T2979Cas No. 89-78-1
Alias Hexahydrothymol, 15356-70-4, (±)-Menthol
DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
DL-Menthol
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Purity: 99.74%
Catalog No. T2979Alias Hexahydrothymol, 15356-70-4, (±)-MentholCas No. 89-78-1
DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 g | $30 | - | In Stock | |
| 5 g | $40 | - | In Stock | |
| 10 g | $56 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.74%
Appearance:Solid
Color:White
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Product Introduction
DL-Menthol AI Summary
DL-Menthol is a multifaceted molecule demonstrating various bioactivities. It functions as an inhibitor of COX2, showing an inhibition rate of less than 30.0% at 100 μM and 60.0% at 0.1 μg/mL. The compound is active in the expressed human recombinant enzymes UGT1A4 and UGT2A1, with activities recorded at 41.0 pm/min/mg and 32.0 pm/min/mg, respectively. It also exhibits lytic activity against Monographella nivalis var. nivalis MAFF 305031, causing 45.7% hyphal lysis at 0.2 mg/ml after 48 hours.
Additionally, DL-Menthol acts as an agonist at TRPM8 in differentiated rat/mouse F11 cells and in human TRPM8 receptors, with EC50 values of 23400.0 nM and 10100.0 nM, respectively. It also activates human TRPA1 receptors with an EC50 of 96000.0 nM. Its agonist activity extends to the N-terminal rat ST3 receptor-fused human TAS2R7 in HEK293T cells, indicating calcium signaling in a concentration-dependent manner up to 2.60 mM.
Further bioactivities include inhibition of human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 50.1 nM, and Cav1.2 calcium current in rabbit ventricular myocytes with an IC50 of 74600.0 nM. It acts as an antagonist on human OR5K1 in HEK293 cells, inhibiting the response to 2,6-dimethylpyrazine by at least 50.0% at 100 μM.
Despite these activities, DL-Menthol has limited effect on the SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity of VERO-6 cells. The compound shows minimal antiviral activity with an 11.1% inhibition of the 3CL-Pro protease at 20 μM and a -0.18% inhibition of cytotoxicity at 10 μM. Activity assays on human HDAC6 report low inhibition rates of 2.89% and -3.28% depending on the substrate used. Lastly, although tested extensively, the compound displayed no significant activity in assays with AC50 values exceeding 30,000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DL-Menthol ((±)-Menthol) is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthod, which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase.2 (+)-Menthol inhibits the growth of F. verticillioides (MIC: 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities. |
| Synonyms | Hexahydrothymol, 15356-70-4, (±)-Menthol |
| Molecular Weight | 156.27 |
| Formula | C10H20O |
| Cas No. | 89-78-1 |
| Smiles | [C@H](C)(C)[C@H]1[C@H](O)C[C@H](C)CC1 |
| Relative Density. | 0.89 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: Soluble H2O: Insoluble DMSO: 245 mg/mL (1567.8 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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