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DIM-C-pPhCO2Me

Catalog No. T5196 CAS 151358-48-4

DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist.

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DIM-C-pPhCO2Me, CAS 151358-48-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 222.00
100 mg	In stock	$ 378.00
200 mg	In stock	$ 521.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.58%

Biological Description

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Description	DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist.
In vitro	DIM-C-pPhCO2Me inhibited growth and induced apoptosis in ACHN and 786-O cells [1]. DIM-C-pPhCO2Me decreased NR4A1-dependent transactivation in RMS cells and inhibited RMS cell and tumor growth and induced apoptosis. Both NR4A1 knockdown and treatment with DIM-C-pPhCO2Me also induced ROS which activated stress genes and induced sestrin 2 which activated AMPK and inhibited mTOR in the mutant p53 RMS cells [2].
Cell Research	Knockdown of NR4A1 in ACHN and 786-O cells was carried out using Lipofectamine 2000 reagent according to the manufacturer's protocol. siRNA complexes used in the study are as follows: siGL2-5', CGU ACG CGG AAU ACU UCG A; siNR4A1 (1)-SASI_Hs02_00333289; siNR4A1 (2)-SASI_Hs01_00182072. ACHN RCC cells were plated on 12-well plates at 5 x 104 cells per well in DMEM supplemented with 2.5% charcoal-stripped FBS. After 24 hr, various amounts of DNA [NBRE3-luc (400 ng), FLAG-NR4A1 (40 ng)] were cotransfected into each well by Lipofectamine 2000 reagent according to the manufacturer's protocol. After 6 hr of transfection, cells were treated with 2.5% stripped DMEM containing either DMSO, DIM-C-pPhOH (20 μM) or DIM-C-pPhCO2Me (15 μM) for 18 hr [1].

Molecular Weight	380.44
Formula	C25H20N2O2
CAS No.	151358-48-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (131.43 mM)

References and Literature

1. Hedrick E, et al. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One. 2015 Jun 2;10(6):e20128308. 2. Lacey A, et al. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. 2016 May 24;7(21):31257-69.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Nuclear Receptor Compound Library Anti-Cancer Compound Library Apoptosis Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-COVID-19 Compound Library

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Keywords

DIM-C-pPhCO2Me 151358-48-4 Others DIMCpPhCO2Me DIM-C-pPhCO-2Me inhibit Inhibitor DIM C pPhCO2Me inhibitor

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