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D-Panthenol

Catalog No. T1437 CAS 81-13-0

Synonyms: D-Pantothenyl alcohol, Ilopan, Dexpanthenol, Pantothenol

Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine. Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.

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D-Panthenol, CAS 81-13-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Dexpanthenol has positive effects on protection of cerebral tissue after ischaemia reperfusion[1]. Topical application of dexpanthenol is widely used in clinical practice for the improvement of wound healing. Upregulation of IL-6, IL-1, CYP1B1, CXCL1, CCL18 and KAP 4-2 gene expression and downregulation of psorasin mRNA and protein expression are identified in samples treated topically with dexpanthenol[2].

Synonyms	D-Pantothenyl alcohol, Ilopan, Dexpanthenol, Pantothenol
Molecular Weight	205.25
Formula	C9H19NO4
CAS No.	81-13-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33 mg/mL (160.78 mM), Need ultrasonic and warming

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zakaria MM, et al. J Pak Med Assoc. 2011, 61(9):889-92. 2. Heise R, et al. Skin Pharmacol Physiol. 2012, 25(5):241-8.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D-Panthenol 81-13-0 Metabolism Endogenous Metabolite DPanthenol Inhibitor D-Pantothenyl alcohol Ilopan Dexpanthenol Pantothenol D Panthenol inhibit inhibitor

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