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Coralyne chloride

Catalog No. T31011 CAS 38989-38-7

Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA cleavage.

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Coralyne chloride, CAS 38989-38-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
2 mg	In stock	$ 45.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 455.00
100 mg	In stock	$ 672.00

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Purity: 99.35%

Biological Description

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Description	Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. It acts as a topoisomerase I toxic molecule, inducing topoisomerase I-mediated DNA cleavage.
In vitro	There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line[2].

Molecular Weight	399.87
Formula	C22H22ClNO4
CAS No.	38989-38-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.5 mg/mL (3.75 mM)

H2O: 3 mg/mL (7.50 mM)

References and Literature

1. Khadka DB, Cho WJ. Topoisomerase inhibitors as anticancer agents: a patent update. Expert Opin Ther Pat. 2013 Aug;23(8):1033-56. 2. Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. 3. Bhadra K, Kumar GS. Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. Med Res Rev. 2011 Nov;31(6):821-62. 4. Giri P, Suresh Kumar G. Molecular recognition of poly(A) targeting by protoberberine alkaloids: in vitro biophysical studies and biological perspectives. Mol Biosyst. 2010 Jan;6(1):81-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Bioactive Compound Library

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Keywords

Coralyne chloride 38989-38-7 DNA Damage/DNA Repair Topoisomerase Coralyne Chloride cancer inhibit neurodrug Inhibitor Coralyne Antileukemic protoberberine topoisomerase I inhibitor

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