Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Citiolone (Thioxidrene) is a thiolic-derived medication as a mucolytic agent for the treatment of certain hepatic disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 33.00 | |
100 mg | In stock | $ 47.00 | |
200 mg | In stock | $ 68.00 | |
500 mg | In stock | $ 112.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Citiolone (Thioxidrene) is a thiolic-derived medication as a mucolytic agent for the treatment of certain hepatic disorders. |
In vitro | OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. In addition, OSI-027 inhibits mTOR signaling of phospho-4E-BP1 with an IC50 of 1 μM in cell-based assays. [1] OSI-027 exhibits anti-proliferative activities against several acute leukemia cell lines of myeloid/megakaryocytic origin in a dose-dependent manner, including U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01 cells. [2] A recent study shows that inhibition of mTORC1/2 by OSI-027 effectively suppresses phosphorylation of Akt (S473) and cell proliferation in breast cancer cells. [3] |
Synonyms | Thioxidrene, Citiolase |
Molecular Weight | 159.21 |
Formula | C6H9NO2S |
CAS No. | 1195-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 29 mg/mL (182.1 mM)
DMSO: 35 mg/mL (219.84mM)
H2O: 29 mg/mL (182.1 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Citiolone 1195-16-0 Others Inhibitor Thioxidrene Citiolase inhibit inhibitor