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CPS-11

Catalog No. T23911 CAS 145945-21-7

Synonyms: CPS11, CPS 11, N-(Hydroxymethyl)thalidomide

CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line.

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CPS-11, CAS 145945-21-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 397.00
5 mg	In stock	$ 970.00
10 mg	In stock	$ 1,180.00
25 mg	In stock	$ 1,580.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 99.55%

Purity: 99.30%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1].
Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2].
At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2].
Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].

Synonyms	CPS11, CPS 11, N-(Hydroxymethyl)thalidomide
Molecular Weight	288.26
Formula	C14H12N2O5
CAS No.	145945-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (173.45 mM), Sonication is recommended.

References and Literature

1. Aragon-Ching JB, et al. Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov. 2007 Jun;2(2):167-74. 2. Warfel NA, et al. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3502-9. 3. Ge Y, et al. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108(13):4126-35. 4. Nishiyama T, Ide T, Himes SR Jr, Ishizaka S, Araki T. Immunodiagnosis of human sparganosis mansoni by micro-chemiluminescence enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg. 1994 Nov-Dec;88(6):663-5. PubMed PMID: 7886764.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CPS-11 145945-21-7 Immunology/Inflammation Metabolism NF-Κb Dehydrogenase NF-κB Reactive Oxygen Species CPS11 CPS 11 N-(Hydroxymethyl)thalidomide inhibitor inhibit

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