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GPCR/G Protein GTPase CCG 203769

CCG 203769

Catalog No. T10705   CAS 410074-60-1

CCG 203769 is a selective inhibitor of G protein signaling (RGS4). It blocks the RGS4-Gαo protein-protein interaction in vitro (IC50: 17 nM).

CCG 203769, CAS 410074-60-1
Pack Size Availability Price/USD Quantity
5 mg Inquiry 346.00
10 mg Inquiry 590.00
25 mg Inquiry 1176.00
50 mg Inquiry Inquiry
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1 mL * 10 mM (in DMSO) Inquiry 380.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CCG 203769 is a selective inhibitor of G protein signaling (RGS4). It blocks the RGS4-Gαo protein-protein interaction in vitro (IC50: 17 nM).
Targets&IC50 RGS4 ,   RGS19 ,   RGS16 ,   RGS8 ,   GSK3β
In vivo Carbamoylcholine chloride (0.1 mg/kg, IP) produces a modest decrease in heart rate compared to that of a saline vehicle control. CCG 203769 (10 mg/kg, IV) has no significant effect upon heart rate when given alone. However, CCG 203769, administered immediately prior to Carbamoylcholine chloride, significantly potentiates the bradycardic effect (p < 0.05). Raclopride administration in rats causes increased hang time in the bar test, which is rapidly reversed by doses of CCG 203769 ranging from 0.1 to 10 mg/kg. The lowest dose, 0.01 mg/kg has no effect, while 0.1 mg/kg produces a submaximal effect. The higher doses, 1 and 10 mg/kg produce equivalent effects. Similarly, the raclopride-induced paw drag in mice is reversed by 0.1-10 mg/kg CCG 203769.
Molecular Weight 202.27
Formula C8H14N2O2S
CAS No. 410074-60-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 62.5 mg/mL (308.99 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Blazer LL, et al. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. ACS Chem Neurosci. 2015 Jun 17;6(6):911-9.

Related Products

Related compounds with same targets
CCG 203769 BQU57 QS 11 CCG 50014 RBC8 Exo-1 Gancaonin I

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.