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RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Name: RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Brand: TargetMol
SKU: TMPJ-00662
Rating: 4.5 (1 reviews)

(Synonyms: tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254) Copy Product Info

Synonyms: tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254

Catalog No. TMPJ-00662 Copy Product Info

Purity: 97%

CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Pack Size	Price	USA Stock	Global Stock
5 µg	$74	7-10 days	7-10 days
10 µg	$118	In Stock	In Stock
20 µg	$187	7-10 days	7-10 days
50 µg	$350	7-10 days	7-10 days
100 µg	$578	7-10 days	7-10 days
200 µg	$965	7-10 days	7-10 days
500 µg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Loaded Recombinant Human OPG-Fc on Pro A Biosensor, can bind Human RANKL with an affinity constant of 1.83 pM as determined in BLI assay. (Regularly tested)
Description	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	O14788
Amino Acid	Ile140-Asp317
Construction	Ile140-Asp317
Protein Purity	Greater than 90% as determined by reducing SDS-PAGE. Greater than 90% as determined by SEC-HPLC. ,
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254
Research Background	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.

Chemical Properties

Molecular Weight

20 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

TNFSF-11TNFSF 11Receptor activator of nuclear factor k-B ligandCD-254CD 254

Related Tags: RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) chemical structure | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) molecular weight