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Bexarotene

Catalog No. T6410 CAS 153559-49-0

Synonyms: Ro 26-4455, Targretin, LGD1069

Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).

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Bexarotene, CAS 153559-49-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 44.00
50 mg	In stock	$ 62.00
100 mg	In stock	$ 91.00
200 mg	In stock	$ 123.00
500 mg	In stock	$ 261.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99%

Purity: 98.12%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).

Kinase Assay

Biacore studies: Competition assays are performed on a Biacore S51. A Series S Sensor chip CM5 is derivatized for immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~ 200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Test compounds are dissolved in DMSO at 10 mM and further diluted to make a concentration series of inhibitor in each MDM2 test sample. The assays are run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of inhibitor is calculated as a percentage of binding in the absence of inhibitor and IC50 is calculated using Microsoft Excel

Synonyms	Ro 26-4455, Targretin, LGD1069
Molecular Weight	348.48
Formula	C24H28O2
CAS No.	153559-49-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 34.9 mg/mL (100 mM)

Ethanol: 7 mg/mL (20 mM)), Heating is recommended.

References and Literature

1. Zhang C, et al. Clin Cancer Res, 2002, 8(5), 1234-1240. 2. Nieto-Rementería N, et al. Br J Dermatol. 2009 Mar;160(3):519-26. 3. Li Y, et al. Br J Cancer, 2008, 98(8), 1380-1388. 4. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue[J]. EBioMedicine. 2018, 37: 344-355. 5. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797. 2. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. EBioMedicine. 2018, 37: 344-355. 3. Ren Q, Xie X, Zhao C, et al. 2, 2′, 4, 4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chemical Research in Toxicology. 2022 4. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bexarotene 153559-49-0 Autophagy Metabolism Retinoid Receptor Ro 26-4455 cutaneous Targretin lymphoma selective,?retinoid inhibit Retinoic acid receptors antineoplastic LGD 1069 LGD-1069 T-cell LGD1069 RAR/RXR Inhibitor anti-cancer Retinoid X receptors RXR inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.