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Benzonatate

Catalog No. T19644   CAS 104-31-4

Benzonatate is an antagonist of sodium channel protein.

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Benzonatate Chemical Structure
Benzonatate, CAS 104-31-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 41.00
10 mg In stock $ 66.00
25 mg In stock $ 132.00
50 mg In stock $ 197.00
100 mg In stock $ 332.00
1 mL * 10 mM (in DMSO) In stock $ 54.00
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Purity: 99.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Benzonatate is an antagonist of sodium channel protein.
In vivo Na(+) currents are inhibited most potently by a benzonatate fraction containing the 9-ethoxy component.?Detectable effects of benzonatate occur at concentrations as low as 0.3 μM, which has been reported in humans. benzonatate has local anesthetic-like effects on voltage-gated sodium channels, including Nav1.7, which is a possible mechanism for cough suppression by the drug.
Molecular Weight 603.74
Formula C30H53NO11
CAS No. 104-31-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (91.1 mM)

TargetMolReferences and Literature

1. Evans M S , Maglinger G B , Fletcher A M , et al. Benzonatate inhibition of voltage-gated sodium currents[J]. Neuropharmacology, 2016, 101:179.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Orally Active Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library Approved Drug Library Bioactive Compound Library Human Metabolite Library

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AZD7507 GX-674 KT-362 fumarate Permethrin Procainamide hydrochloride Sodium ionophore III QX-314 chloride Vindorosine

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Keywords

Benzonatate 104-31-4 Membrane transporter/Ion channel Sodium Channel inhibit tetracaine-like metabolite respiratory stretch receptors Benzononatine antitussive local anesthetic Na channels Inhibitor Na+ channels inhibitor

 

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