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BTT-3033

Catalog No. T26917 CAS 1259028-99-3

Synonyms: BTT3033, BTT 3033

BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BTT-3033, CAS 1259028-99-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 108.00
10 mg	In stock	$ 158.00
25 mg	In stock	$ 266.00
50 mg	In stock	$ 395.00

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Purity: 98.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 induces apoptosis and can be used in the study of prostate cancer, BTT-3033 induces apoptosis and can be used to study prostate cancer, inflammation and cardiovascular disease.
Targets&IC50	α2β1:130 nM (EC50)
In vitro	BTT-3033 and BTT-3034 inhibited cell adhesion to rat tail collagen I with EC50 values of 130 and 160 nM, respectively, and corresponding Emax values of 97 and 86% .Neither BTT-3033 nor BTT-3034 (at EC50 concentrations) inhibited the adhesion of MG-63 cells to vitronectin, 120-kDa fibronectin or 40-kDa fibronectin, assays that measured αV, α5β1, and α4β1 integrin function, respectively [2].
In vivo	Integrin α2β1 function blocking sulfonamides BTT-3016, BTT-3033(oral administration, 10 mg/kg) and BTT-3034 have anti-inflammatory effects in PAF-stimulated air pouch model[1].

Synonyms	BTT3033, BTT 3033
Molecular Weight	465.5
Formula	C23H20FN5O3S
CAS No.	1259028-99-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (214.82 mM), Sonication is recommended.

References and Literature

1. Liisa Nissinen, et al. Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. Pharmacol Res Perspect. 2015 Jun;3(3):e00146. 2. Liisa Nissinen, et al. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012 Dec 28;287(53):44694-702. 3. Bingsheng Li, et al. Inhibition of neurogenic and thromboxane A 2 -induced human prostate smooth muscle contraction by the integrin α2β1 inhibitor BTT-3033 and the integrin-linked kinase inhibitor Cpd22. Prostate. 2020 Aug;80(11):831-849. 4. Zahra Salemi, et al. Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial-mesenchymal transition. J Cell Physiol. 2021 Jul;236(7):4954-4965. 5. Takashi Kanamoto, et al. Integrin α2β1 plays an important role in the interaction between human articular cartilage-derived chondrocytes and atelocollagen gel. Sci Rep. 2021 Jan 19;11(1):1757.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library

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Keywords

BTT-3033 1259028-99-3 Apoptosis Cytoskeletal Signaling Integrin BTT3033 BTT 3033 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.