Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 76.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 413.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 58.00 |
Description | BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). |
Targets&IC50 | LXRβ:14 nM, LXRα:68nM |
In vitro | BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM). |
In vivo | BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2]. |
Synonyms | XL652, EXEL04286652, XL 652, XL-652, BMS-788 |
Molecular Weight | 509.06 |
Formula | C28H29ClN2O3S |
CAS No. | 918348-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (117.86 mM)
You can also refer to dose conversion for different animals. More
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BMS-779788 918348-67-1 Metabolism Liver X Receptor Inhibitor BMS 788 Liver X receptor XL652 inhibit EXEL 04286652 BMS779788 LXR EXEL04286652 XL 652 EXEL-04286652 XL-652 BMS-788 BMS788 BMS 779788 inhibitor