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Aurantiamide acetate

Name: Aurantiamide acetate
Brand: TargetMol
SKU: TJS2216
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJS2216Cas No. 56121-42-7

Alias Asperglaucide

Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

Aurantiamide acetate

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Purity: 99.68%

Catalog No. TJS2216Alias AsperglaucideCas No. 56121-42-7

Pack Size	Price	Availability
1 mg	$106	In Stock
5 mg	$222	In Stock
10 mg	$328	In Stock
25 mg	$552	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Purity:99.68%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].
Targets&IC50	Cathepsin B:49 μM, Cathepsin L:12 μM
In vitro	Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively.
In vivo	Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
Synonyms	Asperglaucide

Chemical Properties

Molecular Weight	444.52
Formula	C₂₇H₂₈N₂O₄
Cas No.	56121-42-7
Smiles	CC(=O)OC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
Relative Density.	1.179 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (123.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2496 mL	11.2481 mL	22.4962 mL	112.4809 mL
5 mM	0.4499 mL	2.2496 mL	4.4992 mL	22.4962 mL
10 mM	0.2250 mL	1.1248 mL	2.2496 mL	11.2481 mL
20 mM	0.1125 mL	0.5624 mL	1.1248 mL	5.6240 mL
50 mM	0.0450 mL	0.2250 mL	0.4499 mL	2.2496 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1248 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc