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Anidulafungin

Catalog No. T6088 CAS 166663-25-8

Synonyms: LY303366, Eraxis, Ecalta

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

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Anidulafungin, CAS 166663-25-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 169.00
50 mg	In stock	$ 261.00
100 mg	In stock	$ 365.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Purity: 100%

Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.
In vitro	Anidulafungin (LY-303366) demonstrates potent in vitro antifungal activity, with minimum inhibitory concentrations (MICs) of ≤0.32 μg/mL against all isolates of Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10). It exhibits significant efficacy against Aspergillus species with a minimum effective concentration (MEC) of 0.02 μg/mL for 90% inhibition (n=20). However, its activity is reduced against Candida parapsilosis (MIC90, 5.12 μg/mL) (n=10), and it is ineffective against C. neoformans (MIC90 >10.24 μg/mL) (n=15) and B. dermatitidis (MIC90, 16 μg/mL) (n=29). Compared to fluconazole, anidulafungin retains low MICs (0.08 to 1.28 μg/mL) against fluconazole-resistant Candida strains, demonstrating a broad range of action. Strains showing resistance to CD101 exhibit a corresponding increase in MIC for anidulafungin and/or caspofungin, highlighting cross-resistance. This strong antifungal activity, notably against Candida species and Aspergillus, contrasts with its limited effects against C. neoformans and B. dermatitidis, for which ketoconazole and amphotericin B show superior efficacy.
Kinase Assay	FITC-S1P quantification/Caliper assay: A 384-well format of the SphK enzyme assay based on separation of FITC-S1P from unreacted FITC-sphingosine substrate using a microfluidic capillary electrophoresis mobility-shift system is developed. Briefly, 3 nM SphK1–His6 is incubated with 1 μM FITC-sphingosine, 20 μM ATP and 10 μM compound (a final concentration of DMSO of 2 %) in a buffer containing 100 mM Hepes (pH 7.4), 1 mM MgCl2,0.01% Triton X-100, 10% glycerol, 100 μM sodium orthovanadate and 1 mM DTT for 1 h in a 384-well Matrical MP-101-1-PP plate. Reaction mixtures (10 μL) are quenched by the addition of 20 μL of 30 mM EDTA and 0.15% Coating Reagent-3 in 100 mM Hepes, and a small aliquot of each reaction (a few nanolitres) is analysed in the Caliper LabChip 3000 instrument under -1.5 psi (psi=6.9 kPa) pressure, a downstream voltage of -1900 V and a sip time of 0.2 s. Phosphorylated fluorescent product and unphosphorylated fluorescent substrate appeared as distinctive peaks and are quantified using the Caliper data.
Cell Research	Anidulafungin is dissolved in DMSO and stored, and then diluted[2]. Stocks of CD101 (formerly SP 3025, biafungin, AF-025) are prepared fresh in 100% DMSO prior to use. The comparator antifungals Anidulafungin (ANF), Caspofungin (CSF), and Amphotericin B (AMB) are also prepared in 100% DMSO. MIC assays are performed via broth microdilution in accordance with CLSI guidelines, with the exception that test compounds are made up at a 50× final assay concentration and 100 μL assay mixture volumes are used (2 μL added to 98 μL of broth containing cells at 0.5×103 to 2.5×103 CFU/mL). All MIC assays are run at least three times, and a representative data set is shown. Quality control (QC) is assessed throughout the study via comparison of MIC values derived for WT C. krusei strain ATCC 6258 for AMB, CSF, and ANF with previously reported CLSI 24-h broth microdilution QC ranges[2].

Synonyms	LY303366, Eraxis, Ecalta
Molecular Weight	1140.24
Formula	C58H73N7O17
CAS No.	166663-25-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (81.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Zhanel GG, et al. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5 2. Locke JB, et al. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6100-7. 3. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. 4. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

Citations

1. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerging Microbes & Infections. 2019, 8(1): 531-541 2. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 2019, 62(5): 450-457

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Infection Compound Library ReFRAME Related Library FDA-Approved Drug Library Clinical Compound Library Anti-Fungal Compound Library NO PAINS Compound Library Anti-COVID-19 Compound Library

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Keywords

Anidulafungin 166663-25-8 Microbiology/Virology Others Antifungal Antibiotic LY303366 Eraxis LY 303366 LY-303366 Ecalta inhibit Fungal Inhibitor inhibitor

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