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Amitraz

Name: Amitraz
Brand: TargetMol
SKU: T1632
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1632Cas No. 33089-61-1

Alias NSC 324552, BTS-27419

Amitraz (NSC 324552) is a white monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.

Amitraz

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Purity: 99.88%

Catalog No. T1632Alias NSC 324552, BTS-27419Cas No. 33089-61-1

Amitraz (NSC 324552) is a white monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$33	In Stock	In Stock
1 g	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Amitraz AI Summary

Amitraz exhibits a wide range of bioactivities across various biological targets and systems. It shows high potency in modulating Lamin A splicing with an EC50 of 0.9 nM, while demonstrating significantly lower potency in other assays such as activating Cytochrome P450 3A4 (39810.7 nM) and thyroid hormone receptor beta (44668.4 nM). The compound functions as both an agonist and antagonist of peroxisome proliferator-activated receptor gamma (PPARγ) with potencies of 39810.7 nM and 50118.7 nM, respectively, and similarly activates Aryl hydrocarbon Receptor (50118.7 nM) and the antioxidant response element (ARE) signaling pathway (24336.5 nM). It induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 33498.3 nM and exhibits modest inhibition of Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 31622.8 nM. In virological assays, it inhibits Ebola virus entry (25118.9 to 631.0 nM) and SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells. In addition to its antiviral capabilities, Amitraz demonstrates antitrypanosomal activity against Trypanosoma cruzi with an EC50 of 16000.0 nM and exhibits cytotoxicity against BESM cells with an EC50 of 33000.0 nM. It acts as a ligand for Alpha-2A adrenergic receptor and Imidazoline I2, Central receptors, showing IC50 values between 47.7 and 926.9 nM. The compound also demonstrates significant insecticidal activity against two-spotted spider mite Tetranychus urticae and shows toxicity to worker Bombus terrestris (bumblebees). Pharmacokinetically, Amitraz influences multiple physiological systems, including liver and kidney function, electrolyte balance, cholesterol metabolism, and various hematological parameters based on DrugMatrix assay results. Furthermore, it inhibits human HDAC6 enzyme activity, suggesting potential bioactivity in modulating epigenetic functions. Overall, Amitraz is a multifunctional molecule with broad-spectrum bioactivities, significant antiviral potential, insecticidal properties, and the ability to modulate multiple physiological and enzymatic pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Amitraz (NSC 324552) is a white monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.
Synonyms	NSC 324552, BTS-27419

Chemical Properties

Molecular Weight	293.41
Formula	C₁₉H₂₃N₃
Cas No.	33089-61-1
Smiles	N(=CN(C=NC1=C(C)C=C(C)C=C1)C)C2=C(C)C=C(C)C=C2
Relative Density.	1.1280 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (170.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4082 mL	17.0410 mL	34.0820 mL	170.4100 mL
5 mM	0.6816 mL	3.4082 mL	6.8164 mL	34.0820 mL
10 mM	0.3408 mL	1.7041 mL	3.4082 mL	17.0410 mL
20 mM	0.1704 mL	0.8521 mL	1.7041 mL	8.5205 mL
50 mM	0.0682 mL	0.3408 mL	0.6816 mL	3.4082 mL
100 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc